Positive regulation of cellular response to insulin stimulus

Across TCGA patient cohorts, RNA activity of the Positive regulation of cellular response to insulin stimulus pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNN1, MYL9, and C7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cellular response to insulin stimulus activity versus CNN1 in UCEC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CNN1 →	+1.555	+0.184	<.001	<.001	3	6
UCEC	MYL9 →	+1.429	+0.338	<.001	<.001	3	5
UCEC	C7 →	+1.358	+0.219	.006	<.001	3	5
LSCC	DCN →	+0.647	+0.164	.005	.002	3	5
UCEC	NECAB1 →	+0.929	+0.331	<.001	<.001	3	5
UCEC	FBLN5 →	+0.798	+0.238	.006	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900078 vs CNN1 — UCEC

Explore this scatter interactively →