Positive regulation of cellular response to insulin stimulus

Across TCGA cell cohorts, RNA activity of the Positive regulation of cellular response to insulin stimulus pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELF1, NAA38, and CDH1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cellular response to insulin stimulus activity versus ELF1 in STOMACH (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ELF1 →	+0.694	+0.089	.003	.005	3	7
STOMACH	NAA38 →	-1.049	-0.167	.002	.001	3	7
LUNG_SCLC	CDH1 →	+2.801	+0.106	.001	<.001	3	7
LUNG_SCLC	ESRP1 →	+2.489	+0.080	<.001	<.001	3	6
URINARY_TRACT	MAP7 →	+1.990	+0.100	<.001	<.001	3	6
LUNG_SCLC	F11R →	+1.594	+0.094	.005	.002	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900078 vs ELF1 — STOMACH

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