Positive regulation of cellular response to insulin stimulus

Across TCGA cell cohorts, RNA activity of the Positive regulation of cellular response to insulin stimulus pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP5PO, CDH2, and PAM, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATP5PO grouped by Positive regulation of cellular response to insulin stimulus-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ATP5PO →	-0.335	-0.261	.007	.007	3	3
LUNG_NSCLC_LUAD	CDH2 →	+0.157	+0.175	.005	.001	3	3
OVARY	PAM →	+0.090	+0.218	.006	.005	3	3
OVARY	SOCS6 →	-0.156	-0.309	.002	.003	3	3
SKIN	ATF6B →	+0.123	+0.276	.009	.005	3	3
LUNG_NSCLC_LUSC	RRM2 →	+0.528	+0.331	.002	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATP5PO by Positive regulation of cellular response to insulin stimulus activity — BLOOD_Lymphoma

Explore this box plot interactively →