Negative regulation of cellular response to insulin stimulus

Across TCGA patient cohorts, RNA activity of the Negative regulation of cellular response to insulin stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FRZB, HAAO, and PLAC9, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cellular response to insulin stimulus activity versus FRZB in PDAC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	FRZB →	+0.642	+0.046	.002	<.001	3	7
LSCC	HAAO →	+0.252	+0.036	<.001	<.001	3	7
PDAC	PLAC9 →	+0.559	+0.033	<.001	<.001	3	7
GBM	SEPTIN4 →	+0.613	+0.030	<.001	.002	3	7
UCEC	TMOD2 →	+0.514	+0.065	<.001	.002	3	7
UCEC	PRKCQ_T538 →	+1.162	+0.045	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900077 vs FRZB — PDAC

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