Negative regulation of cellular response to insulin stimulus

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of cellular response to insulin stimulus pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 42 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Negative regulation of cellular response to insulin stimulus pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and LUAD, show the opposite pattern, with higher activity associated with better survival.

KIRP, LUSC, and SKCM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.571	0.804	.002	68	view →
LUSC	DFS	Quartile	II,III,IV	0.647	0.814	.001	67	view →
SKCM	OS	Tertile	All	0.396	0.247	<.001	65	view →
ACC	OS	Tertile	II,III,IV	0.347	0.720	.001	51	view →
LUAD	DFS	Quartile	All	0.754	0.600	.005	37	view →
KIRC	DFS	Quartile	All	0.577	0.764	<.001	36	view →
HNSC	OS	Quartile	III,IV	0.414	0.776	.004	34	view →
STAD	DFS	Quartile	All	0.378	0.565	.004	31	view →
COAD	DFS	Tertile	III,IV	0.655	0.444	.012	22	view →
BRCA	OS	Quartile	III,IV	0.927	0.767	.011	19	view →
GBM	DFS	Median	All	0.175	0.287	.010	9	view →
UVM	OS	Quartile	All	0.465	0.779	.031	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:1900077–KIRP (OS)

Open the KIRP breakdown →