Regulation of phosphatidylcholine metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of phosphatidylcholine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CAMK1, NOLC1, and ZC3H14_S409, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of phosphatidylcholine metabolic process activity versus CAMK1 in COAD (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CAMK1 →	+0.257	+0.043	<.001	<.001	3	6
BRCA	NOLC1 →	-0.458	-0.057	.008	.001	3	5
GBM	ZC3H14_S409 →	-0.406	-0.076	.002	.002	2	6
GBM	MAOA →	+0.638	+0.100	<.001	<.001	3	5
LUAD	RPP25_S162 →	-0.894	-0.092	.001	.003	3	5
LUAD	CSTF3_S691 →	-0.564	-0.063	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150172 vs CAMK1 — COAD

Explore this scatter interactively →