Regulation of phosphatidylcholine metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of phosphatidylcholine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAPN2, POPDC3, and GNG12, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of phosphatidylcholine metabolic process activity versus CAPN2 in BLOOD_Lymphoma (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CAPN2 →	+3.526	+1.045	.005	.003	3	6
BREAST	POPDC3 →	+2.281	+0.840	.001	.005	3	5
BREAST	GNG12 →	+2.254	+0.787	<.001	.008	3	5
SKIN	PLOD3 →	+1.394	+0.325	.004	<.001	3	4
SKIN	MYO10 →	+1.945	+0.444	<.001	<.001	3	4
SKIN	TSTD1 →	-2.366	-0.389	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150172 vs CAPN2 — BLOOD_Lymphoma

Explore this scatter interactively →