Amyloid-beta clearance by cellular catabolic process

Across TCGA cell cohorts, RNA activity of the Amyloid-beta clearance by cellular catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IQCB1, CCDC14, and CD63, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amyloid-beta clearance by cellular catabolic process activity versus IQCB1 in LUNG_SCLC (Pearson r = -0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	IQCB1 →	-0.905	-1.525	.005	<.001	3	5
STOMACH	CCDC14 →	-1.422	-1.573	.003	<.001	3	5
LUNG_SCLC	CD63 →	+1.395	+1.560	<.001	<.001	3	4
LUNG_SCLC	PLBD2 →	+0.995	+1.421	.008	.001	3	4
STOMACH	CNTRL →	-1.350	-1.564	.001	.001	3	4
PANCREAS	AGAP4 →	-0.742	-1.076	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150094 vs IQCB1 — LUNG_SCLC

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