Amyloid-beta clearance by transcytosis

Across TCGA patient cohorts, RNA activity of the Amyloid-beta clearance by transcytosis pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LRPAP1, SERBP1, and RPS7, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amyloid-beta clearance by transcytosis activity versus LRPAP1 in OV (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LRPAP1 →	+0.311	+0.060	<.001	<.001	3	8
HNSC	SERBP1 →	-0.278	-0.095	<.001	<.001	3	8
HNSC	RPS7 →	-0.321	-0.091	<.001	.006	3	7
CCRCC	VCAN →	+0.833	+0.050	.004	.002	3	6
UCEC	LRP1 →	+0.476	+0.096	<.001	<.001	3	6
BRCA	COL16A1 →	+0.727	+0.046	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150093 vs LRPAP1 — OV

Explore this scatter interactively →