Amyloid-beta clearance by transcytosis

Across TCGA cell cohorts, RNA activity of the Amyloid-beta clearance by transcytosis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HEATR6, MAN1A2, and NCS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HEATR6 grouped by Amyloid-beta clearance by transcytosis-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	HEATR6 →	-0.691	-0.220	.003	.005	3	5
SOFT_TISSUE	MAN1A2 →	-0.874	-0.370	.004	.006	3	5
OESOPHAGUS	NCS1 →	-1.068	-0.220	.002	<.001	3	5
BLOOD_Myeloma	FHL1 →	-4.270	-0.309	.007	.007	2	5
LUNG_NSCLC_LUSC	APLP1 →	-3.134	-0.325	.002	.009	3	4
LUNG_NSCLC_LUSC	PRR15 →	+3.183	+0.295	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HEATR6 by Amyloid-beta clearance by transcytosis activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →