Amyloid-beta clearance by transcytosis

Across TCGA cell cohorts, RNA activity of the Amyloid-beta clearance by transcytosis pathway is significantly associated with the protein abundance of multiple proteins, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PICALM, AP2B1, and LRPAP1, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amyloid-beta clearance by transcytosis activity versus PICALM in LARGE_INTESTINE (Pearson r = 0.67).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PICALM →	+1.061	+0.313	<.001	<.001	3	15
BONE	AP2B1 →	+0.945	+0.437	<.001	<.001	3	12
BLOOD_Myeloma	LRPAP1 →	+1.971	+0.231	<.001	.007	2	12
STOMACH	EMC1 →	+0.899	+0.312	<.001	<.001	3	11
URINARY_TRACT	SEC61B →	+0.964	+0.269	<.001	.001	3	11
URINARY_TRACT	LRP1 →	+2.055	+0.303	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150093 vs PICALM — LARGE_INTESTINE

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