Retrotransposon silencing by heterochromatin formation

Across TCGA patient cohorts, RNA activity of the Retrotransposon silencing by heterochromatin formation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIA1, TMEM251, and KIAA1586, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retrotransposon silencing by heterochromatin formation activity versus TIA1 in GBM (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TIA1 →	+0.828	+0.393	.002	<.001	3	4
GBM	TMEM251 →	+0.511	+0.356	.007	<.001	3	3
GBM	KIAA1586 →	+0.975	+0.393	.001	<.001	3	3
GBM	ZNF134 →	+0.763	+0.393	.004	<.001	3	3
OV	PUM2 →	+0.554	+0.111	.001	.002	3	3
HNSC	ATAD2B →	+0.589	+0.728	.005	.008	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0141005 vs TIA1 — GBM

Explore this scatter interactively →