Disruption of cellular anatomical structure in another organism

Across TCGA patient cohorts, RNA activity of the Disruption of cellular anatomical structure in another organism pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FCGR3B, ADGRG3, and MACIR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Disruption of cellular anatomical structure in another organism activity versus FCGR3B in LSCC (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FCGR3B →	+1.819	+0.208	<.001	<.001	3	5
HNSC	ADGRG3 →	+2.280	+0.175	.007	.004	3	5
UCEC	MACIR →	-1.175	-0.920	.005	.009	3	5
LUAD	NSD1 →	-0.287	-0.273	.001	.003	3	4
LUAD	CXCL8 →	+1.775	+0.258	<.001	<.001	3	4
LSCC	CXCL6 →	+2.688	+0.197	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140975 vs FCGR3B — LSCC

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