Extracellular vesicle biogenesis

Across TCGA cell cohorts, RNA activity of the Extracellular vesicle biogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HOMER1, LRP8, and ZNHIT6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HOMER1 grouped by Extracellular vesicle biogenesis-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	HOMER1 →	+1.698	+0.249	.002	.007	2	6
BLOOD_Leukemia	LRP8 →	+0.910	+0.167	<.001	.006	3	5
STOMACH	ZNHIT6 →	+0.746	+0.165	.006	.008	3	4
STOMACH	TNPO1 →	+0.634	+0.141	.003	.004	3	4
STOMACH	MLXIPL →	-2.975	-0.169	<.001	<.001	3	4
LUNG_SCLC	MALSU1 →	+0.630	+0.313	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HOMER1 by Extracellular vesicle biogenesis activity — BLOOD_Myeloma

Explore this box plot interactively →