Extracellular vesicle biogenesis

Across TCGA pan-cancer cohorts, RNA activity of the Extracellular vesicle biogenesis pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 25 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Extracellular vesicle biogenesis pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and READ, show the opposite pattern, with higher activity associated with better survival.

UVM, UCS, and MESO are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.577	0.910	<.001	108	view →
UCS	DFS	Median	III,IV	0.483	0.125	.001	62	view →
MESO	DFS	Median	II,III,IV	0.287	0.451	.004	48	view →
KIRC	OS	Median	All	0.553	0.685	.007	37	view →
LAML	DFS	Median	All	0.246	0.504	<.001	36	view →
LUSC	DFS	Quartile	All	0.261	0.519	<.001	29	view →
KICH	DFS	Quartile	II,III,IV	0.376	0.891	<.001	25	view →
CESC	DFS	Quartile	All	0.670	0.859	.001	22	view →
KIRP	DFS	Quartile	All	0.367	0.822	.005	17	view →
GBM	DFS	Quartile	All	0.104	0.358	.002	12	view →
LIHC	OS	Tertile	All	0.582	0.771	.005	12	view →
STAD	DFS	Tertile	II,III,IV	0.533	0.686	.032	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0140112–UVM (DFS)

Open the UVM breakdown →