Neuron projection arborization

Across TCGA cell cohorts, RNA activity of the Neuron projection arborization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYB561D1, ZNF350, and PTPRJ, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CYB561D1 grouped by Neuron projection arborization-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CYB561D1 →	-0.831	-0.995	<.001	.003	3	5
LUNG_NSCLC_LUSC	ZNF350 →	-1.600	-1.273	.006	<.001	3	5
LUNG_NSCLC_LUSC	PTPRJ →	-2.281	-1.352	.004	<.001	3	4
LUNG_NSCLC_LUSC	CYREN →	-0.781	-1.003	.006	.002	3	4
LARGE_INTESTINE	MMP1 →	-1.944	-1.106	.007	.003	3	4
SKIN	S100A4 →	-4.490	-1.263	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CYB561D1 by Neuron projection arborization activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →