Tight junction organization

Across TCGA cell cohorts, RNA activity of the Tight junction organization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CREB3L1, SPINK1, and ATP6V0E2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CREB3L1 grouped by Tight junction organization-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CREB3L1 →	-2.691	-0.674	<.001	.003	3	4
LIVER	SPINK1 →	-5.963	-0.229	<.001	<.001	3	3
LIVER	ATP6V0E2 →	+1.799	+0.226	.004	.004	3	3
CNS	TOE1 →	+0.768	+0.811	.001	.005	3	3
CNS	CFAP70 →	-0.466	-0.626	.002	.002	3	3
CNS	VPS37D →	-0.595	-0.530	.002	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CREB3L1 by Tight junction organization activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →