Negative regulation of cold-induced thermogenesis

Across TCGA patient cohorts, RNA activity of the Negative regulation of cold-induced thermogenesis pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APAF1, GCC2, and TLR4, each associated with the pathway in up to 30 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cold-induced thermogenesis activity versus APAF1 in THYM (Pearson r = 0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	APAF1 →	+1.469	+0.052	<.001	<.001	3	30
THYM	GCC2 →	+1.170	+0.049	<.001	<.001	3	30
ACC	TLR4 →	+1.319	+0.025	<.001	<.001	3	30
THYM	DOCK7 →	+0.905	+0.042	<.001	<.001	3	29
THYM	CASD1 →	+1.061	+0.051	<.001	<.001	3	29
THYM	DLSTP1 →	+0.646	+0.050	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0120163 vs APAF1 — THYM

Explore this scatter interactively →