mRNA alternative polyadenylation

Across TCGA cell cohorts, RNA activity of the mRNA alternative polyadenylation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPSF7, PRPF19, and MTA2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, mRNA alternative polyadenylation activity versus CPSF7 in BREAST (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CPSF7 →	+0.929	+0.215	<.001	.001	3	10
LIVER	PRPF19 →	+1.232	+0.256	.004	.001	3	9
OESOPHAGUS	MTA2 →	+0.953	+0.209	.002	<.001	3	9
SKIN	SSRP1 →	+0.706	+0.146	.009	.008	2	9
CNS	WDR74 →	+0.839	+0.164	.006	.005	3	7
OESOPHAGUS	HNRNPUL2 →	+0.842	+0.213	.003	.009	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0110104 vs CPSF7 — BREAST

Explore this scatter interactively →