mRNA alternative polyadenylation

Across TCGA pan-cancer cohorts, RNA activity of the mRNA alternative polyadenylation pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 5 member genes.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher mRNA alternative polyadenylation pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRC and BRCA, show the opposite pattern, with higher activity associated with better survival.

LIHC, UVM, and KIRP are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	II,III,IV	0.473	0.714	<.001	81	view →
UVM	DFS	Quartile	III,IV	0.136	0.832	<.001	80	view →
KIRP	OS	Median	All	0.587	0.795	<.001	72	view →
UCEC	DFS	Tertile	All	0.781	0.900	<.001	70	view →
KICH	DFS	Tertile	All	0.546	0.931	.002	52	view →
CESC	DFS	Median	All	0.766	0.862	.002	40	view →
LUSC	DFS	Median	III,IV	0.204	0.531	<.001	40	view →
OV	OS	Quartile	III,IV	0.229	0.332	.018	38	view →
ACC	DFS	Quartile	II,III,IV	0.125	0.844	.003	24	view →
MESO	DFS	Tertile	II,III,IV	0.322	0.686	.012	21	view →
PAAD	OS	Median	III,IV	0.629	1.000	.022	21	view →
KIRC	DFS	Median	All	0.880	0.722	.002	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0110104–LIHC (OS)

Open the LIHC breakdown →