Cellular response to aldehyde

Across TCGA patient cohorts, RNA activity of the Cellular response to aldehyde pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ALDH1A1, G6PD, and SH3BGRL2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to aldehyde activity versus ALDH1A1 in HNSC (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ALDH1A1 →	+0.907	+0.123	<.001	<.001	3	6
LSCC	G6PD →	+0.564	+0.062	.001	<.001	3	6
LUAD	SH3BGRL2 →	+0.382	+0.057	<.001	.003	3	5
GBM	COLGALT1 →	-0.422	-0.075	.002	.001	3	5
LUAD	ABLIM1_S426 →	+0.675	+0.070	.001	<.001	3	5
BRCA	KRT18 →	+0.610	+0.043	.007	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0110096 vs ALDH1A1 — HNSC

Explore this scatter interactively →