Cellular response to aldehyde

Across TCGA cell cohorts, RNA activity of the Cellular response to aldehyde pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEMA4G, CDC42EP3, and UBTD1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to aldehyde activity versus SEMA4G in PANCREAS (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SEMA4G →	+1.891	+0.370	.007	.001	3	7
LIVER	CDC42EP3 →	-3.698	-0.568	.006	.001	2	8
LIVER	UBTD1 →	-1.835	-0.643	.003	.001	3	7
LIVER	ALDH2 →	+2.022	+0.720	.003	.001	3	7
LIVER	ETS1 →	-3.448	-0.532	.004	.002	3	6
OESOPHAGUS	C10orf55 →	-1.360	-0.520	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0110096 vs SEMA4G — PANCREAS

Explore this scatter interactively →