Regulation of actin filament organization

Across TCGA cell cohorts, RNA activity of the Regulation of actin filament organization pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R12A, UFC1, and OTX2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP1R12A grouped by Regulation of actin filament organization-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	PPP1R12A →	+0.226	+0.038	.007	.003	2	7
STOMACH	UFC1 →	+0.269	+0.042	<.001	.001	3	6
LUNG_SCLC	OTX2 →	+0.162	+0.061	.007	.007	3	4
OVARY	PSPC1 →	-0.260	-0.045	.002	.006	3	4
CNS	DYNLL2 →	+0.226	+0.056	.001	.001	3	4
LUNG_NSCLC_LUAD	FDX1 →	+0.142	+0.033	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP1R12A by Regulation of actin filament organization activity — KIDNEY

Explore this box plot interactively →