Regulation of calcineurin-mediated signaling

Across TCGA cell cohorts, RNA activity of the Regulation of calcineurin-mediated signaling pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDXDC1, POLR3D, and KAT5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PDXDC1 grouped by Regulation of calcineurin-mediated signaling-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PDXDC1 →	-0.523	-0.514	.005	.008	3	4
LUNG_NSCLC_LUAD	POLR3D →	-0.633	-0.715	<.001	.002	3	3
LUNG_NSCLC_LUAD	KAT5 →	-0.668	-0.742	<.001	.001	3	3
CNS	HOMEZ →	+0.678	+0.755	<.001	.004	3	3
PANCREAS	RNF145 →	+0.817	+1.176	.004	.003	3	3
PANCREAS	COQ2 →	+0.578	+1.036	.005	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PDXDC1 by Regulation of calcineurin-mediated signaling activity — LARGE_INTESTINE

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