Ventricular cardiac muscle cell membrane repolarization

Across TCGA patient cohorts, RNA activity of the Ventricular cardiac muscle cell membrane repolarization pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SETDB1_S1066, SPARCL1_S198, and SPTBN1_S257, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ventricular cardiac muscle cell membrane repolarization activity versus SETDB1_S1066 in BRCA (Pearson r = -0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SETDB1_S1066 →	-0.954	-0.054	<.001	<.001	3	9
BRCA	SPARCL1_S198 →	+1.003	+0.048	<.001	<.001	3	9
LUAD	SPTBN1_S257 →	+0.582	+0.046	<.001	<.001	3	9
HNSC	SYNPO2 →	+0.921	+0.068	<.001	<.001	3	9
HNSC	SYNPO2_T755 →	+0.883	+0.066	<.001	<.001	3	9
COAD	TPM1 →	+0.688	+0.025	<.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099625 vs SETDB1_S1066 — BRCA

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