Postsynapse to nucleus signaling pathway

Across TCGA patient cohorts, RNA activity of the Postsynapse to nucleus signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are OSTF1, LAP3, and TXNDC5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Postsynapse to nucleus signaling pathway activity versus OSTF1 in CCRCC (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	OSTF1 →	+0.199	+0.054	.001	.001	3	7
HNSC	LAP3 →	+0.564	+0.096	<.001	<.001	3	7
HNSC	TXNDC5 →	+0.352	+0.059	.001	.001	3	6
HNSC	STAT5A →	+0.340	+0.076	<.001	<.001	3	6
LSCC	TBC1D2B →	+0.245	+0.061	<.001	<.001	3	6
OV	TLN1 →	+0.322	+0.062	<.001	<.001	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099527 vs OSTF1 — CCRCC

Explore this scatter interactively →