Regulation of presynaptic cytosolic calcium ion concentration

Across TCGA patient cohorts, RNA activity of the Regulation of presynaptic cytosolic calcium ion concentration pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STXBP5, IGLV2-18, and L1CAM, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of presynaptic cytosolic calcium ion concentration activity versus STXBP5 in GBM (Pearson r = 0.55).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	STXBP5 →	+0.381	+0.781	<.001	<.001	3	3
UCEC	IGLV2-18 →	+0.560	+0.267	<.001	<.001	3	3
BRCA	L1CAM →	+0.942	+0.951	<.001	<.001	3	3
GBM	NCS1 →	+0.704	+1.185	<.001	<.001	3	3
GBM	SLC2A13 →	+0.557	+0.913	<.001	<.001	3	3
GBM	VPS35_S7 →	+0.836	+0.941	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099509 vs STXBP5 — GBM

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