Regulation of presynaptic cytosolic calcium ion concentration

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of presynaptic cytosolic calcium ion concentration pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 15 member genes.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher Regulation of presynaptic cytosolic calcium ion concentration pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as MESO and LGG, show the opposite pattern, with higher activity associated with better survival.

COAD, MESO, and OV are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Tertile	III,IV	0.449	0.805	<.001	93	view →
MESO	OS	Median	II,III,IV	0.501	0.283	<.001	72	view →
OV	DFS	Quartile	All	0.128	0.253	.001	36	view →
LGG	DFS	Tertile	All	0.557	0.364	<.001	35	view →
STAD	OS	Median	All	0.489	0.640	.004	35	view →
SCLC	DFS	Quartile	All	0.159	1.000	<.001	30	view →
UCS	DFS	Tertile	II,III,IV	0.642	0.149	.005	26	view →
BLCA	OS	Median	All	0.550	0.663	.005	26	view →
KIRC	OS	Median	All	0.698	0.558	.001	24	view →
ESCA	DFS	Median	All	0.579	0.418	.015	24	view →
THCA	DFS	Tertile	III,IV	0.415	0.834	.003	22	view →
LUAD	DFS	Median	All	0.830	0.711	.011	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0099509–COAD (OS)

Open the COAD breakdown →