Regulation of presynaptic cytosolic calcium ion concentration

Across TCGA cell cohorts, RNA activity of the Regulation of presynaptic cytosolic calcium ion concentration pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NBEAL1, POLA1, and GEMIN2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NBEAL1 grouped by Regulation of presynaptic cytosolic calcium ion concentration-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	NBEAL1 →	-0.660	-1.659	.004	.001	3	5
BLOOD_Leukemia	POLA1 →	+0.775	+0.883	<.001	.008	3	4
LUNG_NSCLC_LUAD	GEMIN2 →	-0.665	-0.707	.008	.001	3	4
BREAST	GALM →	-1.602	-0.711	.001	.005	3	3
STOMACH	ZFYVE21 →	+0.900	+1.189	.003	.002	3	3
STOMACH	ANKRD17 →	+0.388	+1.295	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NBEAL1 by Regulation of presynaptic cytosolic calcium ion concentration activity — BLOOD_Lymphoma

Explore this box plot interactively →