Regulation of presynaptic cytosolic calcium ion concentration

Across TCGA cell cohorts, RNA activity of the Regulation of presynaptic cytosolic calcium ion concentration pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOAT2, PAQR8, and CHD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SOAT2 grouped by Regulation of presynaptic cytosolic calcium ion concentration-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SOAT2 →	+0.468	+1.293	.006	<.001	3	4
OESOPHAGUS	PAQR8 →	+0.150	+0.272	.002	<.001	3	3
LUNG_SCLC	CHD1 →	-0.181	-0.678	.007	.004	3	3
SOFT_TISSUE	FAM124B →	+0.408	+1.405	<.001	.003	3	3
SOFT_TISSUE	DPH2 →	+0.381	+1.296	.002	.001	3	3
SOFT_TISSUE	DOCK11 →	+0.194	+1.226	.009	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SOAT2 by Regulation of presynaptic cytosolic calcium ion concentration activity — LUNG_SCLC

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