"Ion channel modulating, G protein-coupled receptor signaling pathway"

pathway activity — cross-omics
GO:0099105Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the "Ion channel modulating, G protein-coupled receptor signaling pathway" pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NUCKS1_S214, C1orf226_S198, and COLGALT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVNUCKS1_S214 →+0.511+0.053.004.00435
PDACC1orf226_S198 →+0.536+0.055.004.00634
PDACCOLGALT1 →-0.353-0.081<.001<.00134
GBMDSTN →+0.213+0.051.001.00834
PDACGAMT →+0.527+0.068<.001<.00134
PDACALDH1A1_S413 →+0.692+0.067<.001<.00134
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration