Neuronal dense core vesicle exocytosis

Across TCGA patient cohorts, RNA activity of the Neuronal dense core vesicle exocytosis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STXBP1, SCAI, and TES, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuronal dense core vesicle exocytosis activity versus STXBP1 in GBM (Pearson r = 0.60).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	STXBP1 →	+0.692	+0.109	<.001	<.001	3	7
GBM	SCAI →	+0.467	+0.135	<.001	<.001	3	5
GBM	TES →	-0.531	-0.110	<.001	<.001	3	5
PDAC	SLC9A3R1_S280 →	-1.222	-0.060	<.001	.001	3	5
LUAD	ACTN1 →	-0.187	-0.094	.002	<.001	3	5
CCRCC	PTPN14_S594 →	-0.471	-0.082	.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099011 vs STXBP1 — GBM

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