Neuronal dense core vesicle exocytosis

Across TCGA pan-cancer cohorts, RNA activity of the Neuronal dense core vesicle exocytosis pathway differs between tumor and matched normal tissue in 11 of the 18 cancer types tested.

The strongest signal is observed in colon adenocarcinoma (COAD), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as LUSC and HNSC, show the opposite pattern, with lower activity in tumor tissue.

COAD, THCA, and LIHC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
COAD	Female	II,III,IV	+0.166	<.001	10	view →
THCA	Male	III,IV	+0.108	<.001	9	view →
LIHC	Female	III,IV	+0.122	<.001	7	view →
LUSC	All	II,III,IV	−0.121	<.001	7	view →
HNSC	All	All	−0.033	.007	6	view →
BRCA	All	III,IV	+0.065	.003	5	view →
LUAD	Female	All	−0.081	<.001	4	view →
KICH	Male	II,III,IV	+0.065	.025	2	view →
UCEC	All	All	−0.056	.014	2	view →
BLCA	Male	IV	−0.114	.016	1	view →
KIRP	Male	All	+0.041	.040	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 11 strongest of 11 lineages.

GO:0099011–COAD

Open the COAD breakdown →