Neuronal dense core vesicle exocytosis

Across TCGA pan-cancer cohorts, RNA activity of the Neuronal dense core vesicle exocytosis pathway is associated with patient survival in 27 of 34 cancer lineages. Pathway activity is summarized from the expression of its 7 member genes.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher Neuronal dense core vesicle exocytosis pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as DLBC and KIRP, show the opposite pattern, with higher activity associated with better survival.

DLBC, KIRP, and UVM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	DFS	Tertile	All	1.000	0.497	.009	38	view →
KIRP	DFS	Median	All	0.973	0.795	.006	38	view →
UVM	DFS	Median	All	0.939	0.500	<.001	35	view →
LGG	DFS	Median	All	0.879	0.785	.001	34	view →
CHOL	DFS	Tertile	All	0.115	0.533	.012	30	view →
COAD	OS	Median	III,IV	0.716	0.844	.011	19	view →
GBM	DFS	Tertile	All	0.297	0.176	.006	13	view →
LUAD	OS	Quartile	All	0.875	0.693	.008	13	view →
STAD	DFS	Tertile	IV	0.635	0.213	.005	12	view →
PCPG	DFS	Quartile	All	0.605	0.903	.020	11	view →
UCEC	OS	Tertile	II,III,IV	0.528	0.677	.008	10	view →
LUSC	OS	Median	All	0.714	0.603	.009	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

GO:0099011–DLBC (DFS)

Open the DLBC breakdown →