Neuronal dense core vesicle exocytosis

Across TCGA patient cohorts, RNA activity of the Neuronal dense core vesicle exocytosis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYO6, MACO1, and CRBN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuronal dense core vesicle exocytosis activity versus MYO6 in BRCA (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MYO6 →	+0.894	+0.830	<.001	<.001	3	5
BRCA	MACO1 →	+0.447	+0.698	<.001	.003	3	5
UCEC	CRBN →	+0.353	+0.692	.001	.004	2	5
BRCA	CPLX1 →	+1.224	+0.732	<.001	<.001	3	4
GBM	CPEB3 →	+0.669	+0.735	<.001	<.001	3	4
BRCA	ARFGEF3 →	+1.271	+0.942	<.001	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099011 vs MYO6 — BRCA

Explore this scatter interactively →