Neuronal dense core vesicle exocytosis

Across TCGA cell cohorts, RNA activity of the Neuronal dense core vesicle exocytosis pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIAE, SLC25A15, and GAD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuronal dense core vesicle exocytosis activity versus SIAE in OVARY (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SIAE →	+1.425	+1.289	.002	.002	3	4
LUNG_SCLC	SLC25A15 →	-0.791	-1.202	<.001	<.001	3	4
LUNG_SCLC	GAD1 →	+1.420	+0.845	.007	.009	3	4
LUNG_SCLC	ZC3H12C →	+1.335	+1.111	<.001	<.001	3	4
LUNG_SCLC	ADAM22 →	+1.299	+1.159	.001	<.001	3	4
LUNG_SCLC	CAV1 →	-3.151	-1.187	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099011 vs SIAE — OVARY

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