Vesicle-mediated transport in synapse

Across TCGA cell cohorts, RNA activity of the Vesicle-mediated transport in synapse pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UAP1L1, ARHGAP1, and TANGO2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle-mediated transport in synapse activity versus UAP1L1 in LUNG_NSCLC_LUSC (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	UAP1L1 →	+1.887	+0.194	<.001	.008	3	5
BREAST	ARHGAP1 →	+0.863	+0.176	<.001	<.001	3	5
SKIN	TANGO2 →	+1.377	+0.228	.001	.007	3	5
OESOPHAGUS	ATP6V1D →	+0.813	+0.223	.002	.001	3	5
OESOPHAGUS	OAZ2 →	+0.742	+0.197	.009	.002	3	5
BONE	RPL31 →	-0.945	-0.356	.004	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099003 vs UAP1L1 — LUNG_NSCLC_LUSC

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