Excitatory chemical synaptic transmission

Across TCGA patient cohorts, RNA activity of the Excitatory chemical synaptic transmission pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARID1A_S382, OXR1, and NEXN_S243, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Excitatory chemical synaptic transmission activity versus ARID1A_S382 in OV (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ARID1A_S382 →	-0.607	-0.070	.001	<.001	3	5
GBM	OXR1 →	+0.326	+0.084	.003	.003	3	5
OV	NEXN_S243 →	+1.223	+0.079	.001	<.001	3	4
UCEC	YWHAZ_S207 →	+0.506	+0.054	<.001	.005	3	4
PDAC	SYNPO2_T755 →	+0.397	+0.059	.006	<.001	3	4
PDAC	FMOD →	+0.478	+0.054	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098976 vs ARID1A_S382 — OV

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