Excitatory chemical synaptic transmission

Across TCGA pan-cancer cohorts, RNA activity of the Excitatory chemical synaptic transmission pathway differs between tumor and matched normal tissue in 12 of the 18 cancer types tested.

The strongest signal is observed in colon adenocarcinoma (COAD), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KIRC and KIRP, show the opposite pattern, with lower activity in tumor tissue.

COAD, KIRC, and KIRP show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
COAD	Male	III,IV	+0.120	<.001	11	view →
KIRC	Male	II,III,IV	−0.073	<.001	9	view →
KIRP	Male	II,III,IV	−0.104	<.001	8	view →
LUAD	All	All	+0.044	<.001	6	view →
READ	All	All	+0.073	<.001	5	view →
KICH	All	All	+0.055	.001	4	view →
PRAD	All	All	+0.028	.001	2	view →
THCA	Female	All	−0.027	.027	2	view →
BRCA	All	III,IV	+0.025	.011	2	view →
LUSC	Female	III,IV	+0.130	.046	1	view →
STAD	Male	IV	+0.125	.026	1	view →
HNSC	All	All	+0.037	.048	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 12 lineages.

GO:0098976–COAD

Open the COAD breakdown →