Excitatory chemical synaptic transmission

Across TCGA cell cohorts, RNA activity of the Excitatory chemical synaptic transmission pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIAA1958, PER2, and NDUFAF5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KIAA1958 grouped by Excitatory chemical synaptic transmission-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	KIAA1958 →	+0.655	+0.983	<.001	.001	3	4
SOFT_TISSUE	PER2 →	+0.634	+1.552	<.001	<.001	3	4
OVARY	NDUFAF5 →	+0.601	+0.864	<.001	.001	3	4
OVARY	ASB6 →	+0.470	+1.310	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	ZNF398 →	+0.710	+1.349	.005	<.001	3	4
OVARY	C20orf194 →	+0.680	+0.968	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KIAA1958 by Excitatory chemical synaptic transmission activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →