Anterograde dendritic transport of neurotransmitter receptor complex

Across TCGA cell cohorts, RNA activity of the Anterograde dendritic transport of neurotransmitter receptor complex pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABI3BP, RXRA, and QRICH2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ABI3BP grouped by Anterograde dendritic transport of neurotransmitter receptor complex-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ABI3BP →	-3.176	-1.304	.008	<.001	3	4
OESOPHAGUS	RXRA →	+0.990	+0.854	.004	.006	3	4
STOMACH	QRICH2 →	+0.681	+1.116	.002	.005	3	3
STOMACH	SNAPC4 →	+0.568	+1.291	<.001	<.001	3	3
URINARY_TRACT	CCNE2 →	+1.133	+2.327	.001	.003	3	3
LUNG_NSCLC_LUSC	ARG1 →	+0.125	+1.546	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ABI3BP by Anterograde dendritic transport of neurotransmitter receptor complex activity — LIVER

Explore this box plot interactively →