Anterograde dendritic transport of neurotransmitter receptor complex

Across TCGA pan-cancer cohorts, RNA activity of the Anterograde dendritic transport of neurotransmitter receptor complex pathway differs between tumor and matched normal tissue in 14 of the 18 cancer types tested.

The strongest signal is observed in kidney chromophobe (KICH), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors.

KICH, COAD, and KIRC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
KICH	Male	III,IV	+0.220	<.001	11	view →
COAD	Male	All	+0.165	<.001	10	view →
KIRC	Male	II,III,IV	+0.052	<.001	10	view →
KIRP	Male	II,III,IV	+0.115	<.001	9	view →
BLCA	All	III,IV	+0.099	<.001	8	view →
THCA	Male	IV	+0.153	.001	7	view →
BRCA	Female	All	+0.122	<.001	6	view →
UCEC	All	All	+0.108	<.001	6	view →
STAD	All	All	+0.117	<.001	5	view →
LUAD	All	All	+0.037	.006	4	view →
LUSC	All	All	+0.048	.002	3	view →
READ	Female	All	+0.282	<.001	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 14 lineages.

GO:0098971–KICH

Open the KICH breakdown →