Anterograde dendritic transport of neurotransmitter receptor complex

Across TCGA cell cohorts, RNA activity of the Anterograde dendritic transport of neurotransmitter receptor complex pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIFAP3, KIFC2, and KIF17, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Anterograde dendritic transport of neurotransmitter receptor complex activity versus KIFAP3 in LIVER (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	KIFAP3 →	+1.473	+0.203	<.001	.001	3	14
BREAST	KIFC2 →	+1.732	+0.129	<.001	.002	2	12
LUNG_NSCLC_LUSC	KIF17 →	-0.817	-0.154	.008	.002	3	10
BONE	KIF5C →	-1.957	-0.141	<.001	.002	3	9
SKIN	MROH1 →	+0.997	+0.144	<.001	<.001	3	9
LUNG_NSCLC_LUAD	TUBB4A →	-1.670	-0.146	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098971 vs KIFAP3 — LIVER

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