Anterograde dendritic transport

Across TCGA patient cohorts, RNA activity of the Anterograde dendritic transport pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HS3ST3B1, CAMSAP3, and KCNMB4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Anterograde dendritic transport activity versus HS3ST3B1 in UCEC (Pearson r = -0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HS3ST3B1 →	-0.928	-0.566	.005	.004	3	4
GBM	CAMSAP3 →	+0.673	+0.269	.003	.005	3	4
GBM	KCNMB4 →	+0.601	+0.256	.005	.004	3	4
HNSC	TLR4 →	-0.478	-0.100	.005	<.001	3	3
HNSC	GCSAM →	-0.625	-0.121	.003	.001	3	3
BRCA	RPSAP22 →	-0.106	-0.152	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098937 vs HS3ST3B1 — UCEC

Explore this scatter interactively →