Intestinal lipid absorption

Across TCGA cell cohorts, RNA activity of the Intestinal lipid absorption pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R1B, GALNT6, and ADGRG1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP1R1B grouped by Intestinal lipid absorption-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PPP1R1B →	+2.437	+1.314	.008	.003	3	5
BLOOD_Myeloma	GALNT6 →	-2.448	-1.360	.009	.005	3	4
LUNG_SCLC	ADGRG1 →	+3.748	+1.462	<.001	<.001	3	4
BLOOD_Leukemia	SLCO5A1 →	+0.770	+1.023	.003	.004	3	4
LUNG_SCLC	PGGHG →	-2.509	-1.142	.003	.002	3	4
CNS	HSPG2 →	-1.648	-0.771	.004	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP1R1B by Intestinal lipid absorption activity — LUNG_SCLC

Explore this box plot interactively →