Intestinal lipid absorption

Across TCGA pan-cancer cohorts, RNA activity of the Intestinal lipid absorption pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 22 member genes.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher Intestinal lipid absorption pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as PRAD and KIRC, show the opposite pattern, with higher activity associated with better survival.

CESC, PRAD, and UCS are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	III,IV	0.582	0.854	.004	36	view →
PRAD	DFS	Tertile	All	0.936	0.827	.001	18	view →
UCS	OS	Quartile	All	0.167	0.447	.002	18	view →
TGCT	DFS	Tertile	All	0.641	0.959	<.001	14	view →
KIRC	DFS	Tertile	All	0.747	0.469	.012	14	view →
STAD	OS	Median	All	0.740	0.597	.005	12	view →
LUSC	DFS	Median	II,III,IV	0.760	0.330	.001	12	view →
LGG	DFS	Median	All	0.794	0.648	.003	11	view →
ACC	OS	Tertile	All	0.909	0.366	.005	11	view →
LAML	DFS	Median	All	0.418	0.707	.003	10	view →
UVM	DFS	Tertile	III,IV	0.452	0.921	.017	10	view →
READ	OS	Median	III,IV	0.403	0.862	.007	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0098856–CESC (DFS)

Open the CESC breakdown →