Response to interleukin-7

Across TCGA patient cohorts, RNA activity of the Response to interleukin-7 pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RTN1, KCNAB2_S9, and CELF2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to interleukin-7 activity versus RTN1 in CCRCC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RTN1 →	+0.432	+0.043	<.001	<.001	3	6
LSCC	KCNAB2_S9 →	+0.576	+0.050	<.001	<.001	3	6
CCRCC	CELF2 →	+0.338	+0.062	<.001	<.001	3	5
LUAD	CMTM4_T208 →	-0.727	-0.044	<.001	<.001	3	5
LSCC	CTNND1 →	-0.234	-0.042	.001	.001	3	5
CCRCC	STK4 →	+0.251	+0.060	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098760 vs RTN1 — CCRCC

Explore this scatter interactively →