Response to interleukin-7

Across TCGA patient cohorts, RNA activity of the Response to interleukin-7 pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SAMSN1, BIRC3, and RASAL3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to interleukin-7 activity versus SAMSN1 in UCEC (Pearson r = -0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SAMSN1 →	+0.677	+0.174	<.001	<.001	3	9
GBM	BIRC3 →	+1.481	+0.163	<.001	<.001	3	8
BRCA	RASAL3 →	+0.853	+0.199	<.001	<.001	3	8
UCEC	BIN2 →	+0.864	+0.246	<.001	<.001	3	8
CCRCC	PTPN22 →	+0.816	+0.211	<.001	<.001	3	8
CCRCC	FCRL3 →	+0.920	+0.180	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098760 vs SAMSN1 — UCEC

Explore this scatter interactively →