Response to interleukin-7

Across TCGA cell cohorts, RNA activity of the Response to interleukin-7 pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRPX, MYO15B, and MYH14, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SRPX grouped by Response to interleukin-7-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SRPX →	+1.401	+1.116	.009	.001	3	4
LARGE_INTESTINE	MYO15B →	-2.386	-1.138	<.001	<.001	3	4
LUNG_SCLC	MYH14 →	-2.600	-1.074	<.001	.001	3	3
LUNG_SCLC	PRCP →	+1.185	+1.139	<.001	<.001	3	3
LIVER	RPL38 →	+0.391	+1.224	.006	<.001	3	3
LUNG_NSCLC_LUSC	FKBP7 →	-2.361	-1.289	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SRPX by Response to interleukin-7 activity — LUNG_SCLC

Explore this box plot interactively →