Maintenance of cell number

Across TCGA patient cohorts, RNA activity of the Maintenance of cell number pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC4, RFC5, and RIF1_S782, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of cell number activity versus RFC4 in COAD (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RFC4 →	+0.686	+2.646	.003	<.001	2	1
COAD	RFC5 →	+0.496	+2.646	.004	<.001	2	1
COAD	RIF1_S782 →	+1.109	+2.646	.001	<.001	2	1
COAD	RNPS1 →	+0.590	+2.556	.003	<.001	2	1
COAD	RPS27L →	+0.826	+2.600	<.001	<.001	2	1
COAD	RREB1_S1219 →	+0.446	+2.443	.005	<.001	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098727 vs RFC4 — COAD

Explore this scatter interactively →